United hosts the Belgian club at Old Trafford in the first leg on August 18/19, before travelling to the Jan Breydel Stadium a week later as Louis van Gaal looks to mastermind a return to the Champions League group stages following last season’s absence.
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Friday’s draw in Nyon also saw Valencia paired with Monaco — beaten in the quarterfinalists last season — and Shakhtar Donetsk handed a tie with Rapid Vienna.
Serie A side Lazio was given a tough tie with Bayer Leverkusen, Sporting Lisbon goes head to head with CSKA Moscow and Scottish champion Celtic will face its Swedish counterpart Malmo.
Other ties see Astana meet APOEL, Skenderbeu play Dinamo Zagreb, Basel face Maccabi Tel Aviv and BATE take on Partizan.
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Draw in full:
Astana v APOEL Skenderbeu v Dinamo Zagreb Celtic v Malmo Basel v Maccabi Tel Aviv BATE v Partizan Lazio v Bayer Leverkusen Manchester United v Club Brugge Sporting Lisbon v CSKA Moscow Rapid Vienna v Shakhtar Donetsk Valencia v Monaco
