San Diego running back Danny Woodhead, who got the start against Buffalo in place of injured feature back Ryan Mathews, sustained a serious ankle injury. ESPN.com reports that Woodhead has a severe high ankle sprain with a fractured fibula.
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Fox Sports reports that Woodhead could get a second opinion, but may require surgery on his right leg.
Donald Brown is the Chargers’ replacement, and they were able to score on the drive with a screen pass to Eddie Royal.